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The Hycamtin.com Web site contains links to third-party cancer-related Web sites on the Internet. We hope these will be useful resources for both you and your patients.

American Association for Respiratory Care (AARC)

(972) 243-2272
www.aarc.org
The AARC interacts with local, state, and federal government on public policy related to respiratory care. The Web site lists respiratory health tips for patients with respiratory problems.

American Cancer Society (ACS)

(800) ACS-2345
www.cancer.org
1599 Clifton Road, NE
Atlanta, GA 30329-4251
The ACS is a nationwide, community-based, voluntary health organization dedicated to eliminating cancer as a major health problem.

American Lung Association

800-586-4872
www.lungusa.org
The American Lung Association is a nationwide, voluntary health organization dedicated to developing programs and strategies to fight lung disease in all its forms.

American Medical Association (AMA)

(312) 464-5000
www.ama-assn.org/ama/pub/category/3158.html
515 North State Street
Chicago, IL 60610
The AMA provides information on doctors, such as when they were licensed, their specialties, and board certifications. The Directory of Medical Specialists lists qualifications of medical doctors and should be available in medical libraries and the public library.

American Society of Clinical Oncology (ASCO)

(703) 299-0150
www.asco.org
1900 Duke Street, Suite 200
Alexandria, VA 22314
ASCO can provide referrals to gynecologic oncologists in your area.

CancerCare, Inc.

(800) 813-HOPE (Long Island); (212) 712-8400 (New York City)
www.cancercare.org
275 Seventh Avenue
New York, NY 10001
CancerCare, Inc., is a national nonprofit agency dedicated to providing emotional support, information, referral, and practical assistance at no charge to people with cancer and their loved ones.

CancerFacts.com

877-422-3228
www.cancerfacts.com
CancerFacts.com—an online resource for cancer patients, their families, and caregivers—is dedicated to delivering accurate and personalized information at a time of need.

Cancer Hope Network

1-877-HOPENET
Two North Road
Chester, NJ 07930
www.cancerhopenetwork.org
Provides support by matching cancer patients with trained volunteers who are cancer survivors themselves. Formerly known as CHEMOcare.

Cancer Information Service

(800) 4-CANCER
(800) 332-8615 (TTY for deaf and hard-of-hearing callers)
9:00 AM-4:30 PM local time, Monday through Friday
www.cancernet.nci.nih.gov
The Cancer Information Service is a national information and education network sponsored by the National Cancer Institute. Information is available in English and Spanish.

CanSurmount

(800) ACS-2345
CanSurmount, an ACS program, provides short-term visitor programs for cancer patients and family members in the hospital and/or at the home for support and encouragement.

Continental Care Force

(281) 261-6626
Provides free air transportation to medical patients with financial need.

Coping With Cancer Magazine

(615) 790-2400
PO Box 682268
Franklin, TN 37068-2268
This is a bimonthly magazine for people who have been touched by cancer. Issues include patient education articles by health care professionals.

Corporate Angel Network

(914) 328-1313
www.corpangelnetwork.org
One Loop Road
White Plains, NY 10604
Corporate Angel Network is a nonprofit organization that finds space on corporate jets, at no charge to the patient, for cancer patients and one attendant/family member needing transportation for treatment, consultation, and checkups.

Lance Armstrong Foundation

(512) 236-8820
www.livestrong.org
PO Box 161150
Austin, TX 78716-1150
The Foundation focuses on cancer survivorship issues for people living with, through, and beyond cancer.

LungCancer.org

1-877-646-LUNG
www.lungcancer.org
Provides links to various support and advocacy groups, as well as a link to information about various methods of screening for cancer.

Lung Cancer Alliance

800-298-2436
www.lungcanceralliance.org
A nationally based organization devoted to improving the quality of life of people with lung cancer through education, support, advocacy, and rehabilitation.

National Cancer Institute (NCI)

(800) 4-CANCER
www.cancernet.nci.nih.gov
The NCI provides a nationwide telephone service for cancer patients and their families and friends, the public, and health care professionals that answers questions and sends booklets and information about cancer.

National Coalition for Cancer Survivorship

(877) NCCS-YES
www.cansearch.org
1010 Wayne Avenue, Suite 770
Silver Spring, MD 20910
The NCCS raises awareness of cancer survivorship through its publications, quarterly newsletters, education to eliminate the stigma of cancer, and advocacy for insurance, employment, and legal rights for people with cancer.

National Hospice and Palliative Care Organization

(800) 646-6460
www.nhpco.org
1700 Diagonal Road, Suite 625
Alexandria, VA 22314
The National Hospice Organization is an association of groups that provide hospice care. Founded in 1978 to promote and maintain quality hospice care and encourage support for patients and family members, this organization can provide information on local hospices.

Oncolink

Abramson Cancer Center of the University of Pennsylvania
3400 Spruce Street—2 Donner
Philadelphia, PA 19104
www.oncolink.com
Oncolink was designed to make it easy for the general public to navigate through the latest cancer information. The Web site is updated every day with information at various levels, from introductory to in-depth.

People Living With Cancer

703-797-1914
www.plwc.org
People Living With Cancer, the patient information Web site of the American Society of Clinical Oncology (ASCO), is designed to help patients and families make informed health-care decisions. The site provides information on more than 85 types of cancer, clinical trials, coping, side effects, a Find an Oncologist database, patient support organizations, and more.

The Wellness Community

(888) 793-WELL
www.thewellnesscommunity.org
919 18th Street NW, Suite 54
Washington, DC 20006
The Wellness Community provides free psychosocial support to people fighting to recover from cancer as an adjunct to conventional medical treatment.

Disclaimer

These sites are not part of Hycamtin.com, a GlaxoSmithKline Web site. The content and materials in these third-party Web sites are not produced or endorsed by GlaxoSmithKline.

Some of these third-party Web sites may refer to uses of our products that are not recommended by GlaxoSmithKline. You should always consult with your physician or health care professional before using any GlaxoSmithKline prescription product.

Important Safety Information

Contraindications

Hycamtin is contraindicated in patients who have a history of hypersensitivity reactions to topotecan or to any of its ingredients. Hycamtin should not be used in patients who are pregnant or breast-feeding, or those with severe bone marrow depression.

Warnings

Hycamtin should be used only in patients with adequate bone marrow reserves, including baseline neutrophil counts of at least 1,500 cells/mm³ and platelet counts of at least 100,000/mm³. Frequent monitoring of blood counts should be instituted during treatment with Hycamtin.

Patients should not be treated with subsequent courses of Hycamtin until neutrophils recover to >1,000 cells/mm³, platelets recover to >100,000 cells/mm³, and hemoglobin levels recover to 9.0 g/dL (with transfusion if necessary).

Hycamtin may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant during therapy with Hycamtin.

Drug Interactions

Concomitant administration of G-CSF can prolong the duration of neutropenia, so if G-CSF is to be used, it should not be initiated until day 6 of the course of therapy, 24 hours after completion of treatment with Hycamtin.

Myelosuppression was more severe when Hycamtin was given in combination with cisplatin in phase I studies. In a reported study on concomitant administration of cisplatin 50 mg/m² and Hycamtin at a dose of 1.25 mg/m²/day x 5 days, 1 of 3 patients had severe neutropenia for 12 days, and a second patient died with neutropenic sepsis. There are no adequate data to define a safe and effective regimen for Hycamtin and cisplatin in combination.

Adverse Events

Frequently reported nonhematologic adverse events associated with use of Hycamtin included nausea (64%), vomiting (45%), diarrhea (32%), alopecia (49%), fatigue (29%), and dyspnea (22%). Most nonhematologic toxicities were grade 1 or 2.

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