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The Hycamtin.com Web site contains links to third-party, cancer-related Web sites on the Internet. We hope these will be useful resources for both you and your patients.

American Cancer Society (ACS)

(800) ACS-2345
www.cancer.org
1599 Clifton Road, NE
Atlanta, GA 30329-4251
The ACS is a nationwide, community-based, voluntary health organization dedicated to eliminating cancer as a major health problem.

American College of Medical Genetics

www.acmg.net
Its Web site includes “Genetic Susceptibility to Breast and Ovarian Cancer: Assessment, Counseling and Testing Guidelines” (produced in collaboration with the NYS Department of Health). The guidelines are also available on the NYS Department of Health Web site at www.health.state.ny.us (click on "Health Care Professionals & Patient Safety" and then "Clinical Guidelines").

American College of Obstetricians and Gynecologists

(202) 638-5577
www.acog.org
409 12th Street SW
Washington, DC 20090-6920
The American College of Obstetricians and Gynecologists is a professional organization of physicians who specialize in women’s health care.

American Medical Association (AMA)

(312) 464-5000
www.ama-assn.org/ama/pub/category/3158.html
515 North State Street
Chicago, IL 60610
The AMA provides information on doctors, such as when they were licensed, their specialties, and board certifications. The Directory of Medical Specialists lists qualifications of medical doctors and should be available in medical libraries and the public library.

American Society of Clinical Oncology (ASCO)

(703) 299-0150
www.asco.org
1900 Duke Street, Suite 200
Alexandria, VA 22314
ASCO can provide referrals to gynecologic oncologists in your area.

CancerCare, Inc.

(800) 813-HOPE (Long Island); (212) 712-8400 (New York City)
www.cancercare.org
275 Seventh Avenue
New York, NY 10001
CancerCare, Inc., is a national nonprofit agency dedicated to providing emotional support, information, referral, and practical assistance at no charge to people with cancer and their loved ones.

Cancer Information Service

(800) 4-CANCER
(800) 332-8615 (TTY for deaf and hard-of-hearing callers)
9:00 AM-4:30 PM local time, Monday through Friday
www.cancernet.nci.nih.gov
The Cancer Information Service is a national information and education network sponsored by the National Cancer Institute. Information is available in English and Spanish.

Cancer Risk Assessment Survey

Women’s Cancer Network
www.wcn.org/interior.cfm?diseaseid=13&featureid=3
The Cancer Risk Assessment Survey is an online, interactive cancer risk assessment survey that helps identify risk level for the gynecologic cancers.

CanSurmount

(800) ACS-2345
CanSurmount, an ACS program, provides short-term visitor programs for cancer patients and family members in the hospital and/or at the home for support and encouragement.

Centers for Disease Control and Prevention

Division of Cancer Prevention & Control
(800) CDC-INFO
www.cdc.gov/cancer/index.htm
4770 Buford Highway NE, MS K64
Atlanta, GA 30341

Continental Care Force

(281) 261-6626
Provides free air transportation to medical patients with financial need.

Coping With Cancer Magazine

(615) 790-2400
PO Box 682268
Franklin, TN 37068-2268
This is a bimonthly magazine for people who have been touched by cancer. Issues include patient education articles by health care professionals.

Corporate Angel Network

(914) 328-1313
www.corpangelnetwork.org
One Loop Road
White Plains, NY 10604
Corporate Angel Network is a nonprofit organization that finds space on corporate jets, at no charge to the patient, for cancer patients and one attendant/family member needing transportation for treatment, consultation, and checkups.

Look Good...Feel Better

(800) 395-LOOK
www.lookgoodfeelbetter.org
CTFA Foundation
1101 17th Street NW
Washington, DC 20036
Co-sponsored by the Cosmetic, Toiletry and Fragrance Association, the American Cancer Society, and the National Cosmetology Association, this public service program teaches women ways to cope with appearance-related side effects of cancer treatment.

National Cancer Institute (NCI)

(800) 4-CANCER
www.cancernet.nci.nih.gov
The NCI provides a nationwide telephone service for cancer patients and their families and friends, the public, and health care professionals that answers questions and sends booklets and information about cancer.

National Cervical Cancer Coalition (NCCC)

(800) 685-5531
www.nccc-online.org
The NCCC, founded in 1997, is a grassroots nonprofit organization dedicated to serving women with, or at risk for, cervical cancer and HPV disease.

National Coalition for Cancer Survivorship

(877) NCCS-YES
www.cansearch.org
1010 Wayne Avenue, Suite 770
Silver Spring, MD 20910
The NCCS raises awareness of cancer survivorship through its publications, quarterly newsletters, education to eliminate the stigma of cancer, and advocacy for insurance, employment, and legal rights for people with cancer.

National Hospice and Palliative Care Organization

(800) 646-6460
www.nhpco.org
1700 Diagonal Road, Suite 625
Alexandria, VA 22314
The National Hospice Organization is an association of groups that provide hospice care. Founded in 1978 to promote and maintain quality hospice care and encourage support for patients and family members, this organization can provide information on local hospices.

Office on Women’s Health

Department of Health and Human Services
(800) 994-9662
www.4woman.gov

Oncolink: The University of Pennsylvania Cancer Center Online Resource

www.oncolink.upenn.edu
Oncolink is a comprehensive information source, including links to online discussion groups.

Society of Gynecologic Nurse Oncologists (SGNO)

(314) 644-4900
www.sgno.org
1610 South Big Bend Boulevard
St. Louis, MO 63117

Society of Gynecologic Oncologists (SGO)

(312) 235-4060
www.sgo.org
230 West Monroe, Suite 710
Chicago, IL 60606
The SGO provides referrals to gynecologic oncologists.

The Wellness Community

(888) 793-WELL
www.thewellnesscommunity.org
919 18th Street NW, Suite 54
Washington, DC 20006
The Wellness Community provides free psychosocial support to people fighting to recover from cancer as an adjunct to conventional medical treatment.

Women’s Cancer Network

www.wcn.org
The Women’s Cancer Network is an interactive Internet site that offers understandable medical information about gynecologic cancers, treatment options, and experimental programs. By answering specific questions a woman will be told her risk for developing specific cancers such as gynecologic, breast, and colon cancers, and how to change those risks.

Disclaimer

These sites are not part of Hycamtin.com, a GlaxoSmithKline Web site. The content and materials in these third-party Web sites are not produced or endorsed by GlaxoSmithKline.

Some of these third-party Web sites may refer to uses of our products that are not recommended by GlaxoSmithKline. You should always consult with your physician or health care professional before using any GlaxoSmithKline prescription product.

Important Safety Information

Contraindications

Hycamtin is contraindicated in patients who have a history of hypersensitivity reactions to topotecan or to any of its ingredients. Hycamtin should not be used in patients who are pregnant or breast-feeding, or those with severe bone marrow depression.

Warnings

Hycamtin should be used only in patients with adequate bone marrow reserves, including baseline neutrophil counts of at least 1,500 cells/mm³ and platelet counts of at least 100,000/mm³. Frequent monitoring of blood counts should be instituted during treatment with Hycamtin.

Patients should not be treated with subsequent courses of Hycamtin until neutrophils recover to >1,000 cells/mm³, platelets recover to >100,000 cells/mm³, and hemoglobin levels recover to 9.0 g/dL (with transfusion if necessary).

Hycamtin may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant during therapy with Hycamtin.

Drug Interactions

Concomitant administration of G-CSF can prolong the duration of neutropenia, so if G-CSF is to be used, it should not be initiated until day 6 of the course of therapy, 24 hours after completion of treatment with Hycamtin.

Myelosuppression was more severe when Hycamtin was given in combination with cisplatin in phase I studies. In a reported study on concomitant administration of cisplatin 50 mg/m² and Hycamtin at a dose of 1.25 mg/m²/day x 5 days, 1 of 3 patients had severe neutropenia for 12 days, and a second patient died with neutropenic sepsis. There are no adequate data to define a safe and effective regimen for Hycamtin and cisplatin in combination.

Adverse Events

Frequently reported nonhematologic adverse events associated with use of Hycamtin included nausea (64%), vomiting (45%), diarrhea (32%), alopecia (49%), fatigue (29%), and dyspnea (22%). Most nonhematologic toxicities were grade 1 or 2.

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